The first generation of the Nissan Qashqai went on sale in February 2007, with close to 100,000 sold across Europe before the end of the year.
Since then, more than 2.3 million have been produced in Sunderland.
In 2016, Nissan sold 261,429 Qashqai in Europe alone. Overall global sales stand at 3.3 million across 137 countries.
Paul Willcox, chairman of Nissan Europe, said: "When the Qashqai launched in 2007 it was unique in the market place.
"It has remained as the number one crossover because it has stayed true to its original ideals, and because we have innovated and consistently added technology through the life of the car."
Late last year, Nissan confirmed it would build the new Qashqai model - as well as the X-Trail SUV - at its Sunderland plant, securing 7,000 jobs.
The company said its decision follows the government's commitment to ensure that its Wearside operation "remains competitive".